Using DNA Origami to Create 2D Structures
Scientists at New York University and the University of Melbourne have developed a method using DNA origami to turn one-dimensional nano materials into two dimensions. Their breakthrough offers the potential to enhance fiber optics and electronic devices by reducing their size and increasing their speed. “We can now take linear nano-materials and direct how they are organized in two dimensions, using a DNA origami platform to create any number of shapes,” explains NYU Chemistry Professor Nadrian Seeman, the paper’s senior author, who founded and developed the field of DNA nanotechnology, now pursued by laboratories around the globe, three decades ago.
Seeman’s collaborator, Sally Gras, an associate professor at the University of Melbourne, says, “We brought together two of life’s building blocks, DNA and protein, in an exciting new way. We are growing protein fibers within a DNA origami structure.” DNA origami employs approximately two hundred short DNA strands to direct longer strands in forming specific shapes. In their work, the scientists sought to create, and then manipulate the shape of, amyloid fibrils—rods of aggregated proteins, or peptides, that match the strength of spider’s silk. To do so, they engineered a collection of 20 DNA double helices to form a nanotube big enough (15 to 20 nanometers—just over one-billionth of a meter—in diameter) to house the fibrils.